Tratamento da toxoplasmose congênita em crinaças: uma revisão de escopo

Abstract

Introduction: Congenital toxoplasmosis is a parasitosis of worldwide relevance, responsible for potentially severe sequelae. The frequency of disease-related complications is higher in southern hemisphere countries due to lower rates of treatment during prenatal care and the presence of more virulent strains. Objective: The purpose of this study is to promote a scoping review about treatment options for congenital toxoplasmosis. Method: The methodological design used was a scoping review in search of answers to the elaborated question: “What are the possible treatments for congenital toxoplasmosis?” We searched eight databases in October 2021. Results: The search found 2488 studies, of which five were selected and analyzed in this review. The texts were characterized by the number of participants and lenght of the study; intervention, expected outcomes and main results. Moreover, the product of this dissertation is the Health Technology Assessment (HTA) that evaluated the sulphadoxine associated with pyrimethamine regimen (sulphadoxine/ pyrimethamine) versus sulfadiazine associated pyrimethamine (sulfadiazine/ pyrimethamine) to treat children with congenital toxoplasmosis. Conclusions: From the analysis of the selected material, it is possible to conclude that 1) Although there is no consensual proposal for the treatment of congenital toxoplasmosis, the association of sulfonamide and pyrimethamine is protective of complications and sequelae due to the disease; 2) That sulfadoxine does not seem to be superior to sulfadiazine as an alternative to the sulfonamide first choice and 3) There is an urgent need to direct efforts to expand search for evidences to underlay the proposition of forms to treat congenital toxoplasmosis treatment. In addition, Primary Health Care in Brazil is the strategic locus to booster the health actions necessary to face congenital toxoplasmosis.